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Family balancing

Family balancing, otherwise known as ‘gender selection’ allows for parents to determine whether they’ll add a baby boy or baby girl to their family

The gender of an embryo can be determined by use of pre-implantation genetic testing (PGT-A).

Treatment follows the same routine as IVF (and ICSI), the only difference being that the resulting embryos undergo a biopsy when they reach blastocyst stage. This biopsy occurs in our in-house laboratory and the embryos are then frozen.

Later, the embryo(s) of the desired gender are transferred to the patient’s womb in a subsequent frozen embryo transfer (FET) cycle.

Pre-implantation genetic testing (PGT-A)

What is PGT-A?

Pre-implantation genetic testing (PGT-A) is a specialised technique that tests the embryo for chromosomal abnormalities before transfer to the womb. The primary aim is to increase the likelihood that a healthy embryo will implant and reduce the risk of miscarriage. PGT-A is also expected to reduce the incidence of foetal abnormality and birth defects related to chromosomal disorders.

PGT-A can also be used to determine the gender of an embryo.

How does it work?

IVF/ICSI treatment to obtain embryos

Embryos are incubated in Bourn Hall Clinic Laboratory until they reach blastocyst stage (usually 5 days after fertilisation)
A biopsy is performed on each embryo. This involves the removal of approx. 5 cells per embryo which are sent to Genetic Laboratories who perform the genetic analysis. Meanwhile, the embryos are frozen and stored at Bourn Hall whilst results are awaited.

A normal embryo (of desired gender, if applicable) is transferred to the woman’s womb in a frozen embryo transfer (FET) cycle. 

Embryos reported as abnormal are removed from storage and allowed to perish, provided patients give their consent to do so. 

Who is PGT-A for?

Pre-implantation genetic testing may be appropriate for:
  • Couples who wish to know the gender of their future baby
  • Older women who have an increased risk of chromosomal abnormality
  • Women who have experienced recurrent miscarriage or multiple IVF failure
  • Couples with severe male-factor infertility

What are the risks of PGT-A?

There are no risks to the patient (other than those present for IVF in general). However, there is a risk that a patient may have fewer or no embryos available for transfer if some or all embryos are reported as abnormal.

As with any laboratory procedure, there’s a very small chance that an embryo could be damaged during the biopsy but this risk is less than 1%.

Thousands of babies have been born as a result of IVF with PGT-A with no reported increase of congenital abnormalities above the general rate for children born with the help of IVF. Although there is currently no evidence that PGT-A poses any risk to children born, there have not yet been sufficient PGT-A cases globally to absolutely rule out any detrimental effect on child development.

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